Diet/Physical Activity Intervention Not More Effective Than Self-Directed Programs for Weight Loss in ALL Survivors
- June 6, 2021
- Posted by: BeTranced Online Holistic Healing Centre
- Category: Blog
A low-calorie weight loss program and bodily exercise intervention didn’t lead to higher weight reduction or scale back cardiovascular (CV) danger components in survivors of childhood ALL, regardless of the success of this intervention among the many common inhabitants. These findings had been introduced on the 2021 American Society of Scientific Oncology (ASCO) Annual Assembly.
Survivors of childhood acute lymphoblastic leukemia (ALL) are in danger for weight problems and cardiovascular (CV) illness. The dangers are elevated for these uncovered to cranial radiotherapy (CRT). A weight reduction intervention comprising a low-calorie DASH weight loss program and bodily exercise was profitable within the common inhabitants; due to this fact, the Train and High quality Weight loss plan After Leukemia: The EQUAL Research (ClinicalTrials.gov Identifier: NCT02244411) sought to find out whether or not this intervention might lead to weight reduction or enhance CV danger components for ALL survivors.
Researchers recruited 358 grownup (18 years and older) 5-year survivors whose ALL was recognized earlier than age 21 years from the Childhood Most cancers Survivor Research (CCSS) and reported weight problems or chubby on the newest CCSS questionnaire. The members had been randomly assigned to the intervention group (181 members; imply weight, 98.7±24.1 kg) or the management group (177 members; imply weight, 95.0±20.3 kg), stratified by CRT publicity.
The intervention was Healthways at Hopkins, a weight loss program and bodily exercise program delivered by way of an app/web site and weekly coach name. The management group members adopted a self-directed weight reduction program.
The first endpoint was distinction in weight reduction between the teams at 24 months. Secondary endpoints had been variations in modifications in blood stress, ldl cholesterol, and triglycerides. Analyses had been carried out utilizing linear blended results; the research was designed to detect a distinction of two.75 kg.
After controlling for CRT, intercourse, race/ethnicity, and age, the adjusted imply change (SE) in weight from baseline at 12 months was -1.83 kg (0.7) within the intervention group and -0.16 kg (0.64) within the management group, with a median distinction of -1.67 (95% CI, -3.5 to 0.2) between the teams.
Fifty-five (30%) intervention group members had been adherent past 1 12 months. At 24 months, the burden modifications had been -0.36 kg (0.78) within the intervention group and +0.18 kg (0.66) for the management members, with a median distinction of -0.54 kg (95% CI, -2.5 to 1.5; P =.59) between the teams.
At 24 months, 24.2% and 17.1% of members within the intervention and management teams, respectively, achieved a weight lack of at the least 5% beneath their baseline weight; 10.9% and 10.3%, respectively, achieved a weight lack of at the least 10% beneath their baseline weight. No important variations in CV danger components had been noticed.
“A 24-month weight loss program and bodily exercise intervention that was profitable for weight reduction within the common inhabitants didn’t lead to higher weight reduction or enhancements in secondary measures, when in comparison with self-directed weight reduction,” concluded the researchers. Nonetheless, these findings could also be as a consequence of lowered adherence past 12 months or the shortage of tailoring to the ALL survivor inhabitants. The researchers additionally be aware that etiology of weight problems in ALL survivors might differ from the final inhabitants.
Disclosures: This analysis was supported by US Nationwide Institutes of Well being. Some research authors declared affiliations with biotech, pharmaceutical, and/or machine corporations. Please see the unique reference for a full record of authors’ disclosures.
Learn extra of Oncology Nurse Advisor’s protection of the 2021 ASCO Annual Assembly by visiting the conference page.
Tonorezos ES, Clark JM, Moskowitz CS, et al. Exercise and QUality diet After Leukemia (The EQUAL Study): an intervention trial in the Childhood Cancer Survivor Study (CCSS). J Clin Oncol. 2021;39(suppl15; abstr 10015). doi:10.1200/JCO.2021.3.9.15_suppl.10015